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Helicobacter Pylori Serology in Patients with Chronic Nonspecific Pharyngitis

Received: 24 November 2021    Accepted: 31 December 2021    Published: 14 January 2022
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Abstract

Sore throat is the most common complaint in ENT OPD with most of the patients suffering from pharyngitis. Chronic nonspecific pharyngitis is a very common presentation among these patients with majority experiencing only temporary relief with medications. Such patients commonly complain of burning in throat and retrosternal burning. In practice, this leads to recurrent visit of patient to the physician and otorhinolaryngologist with only temporary relief. Many of these patients have H. pylori colonization. Although H. pylori usually colonizes in gastric mucosa but there are some reports of extra gastric colonization including pharyngeal and laryngeal mucosa. To detect the presence of Helicobacter pylori there are a number of different investigations. These investigations include H. pylori serology, swab culture, stool culture and urease breath test. H. pylori serology is a very cost effective method for quick diagnosis of such patients. Eradication of H. pylori is essential for long lasting relief in these cases of chronic nonspecific pharyngitis. We have conducted a prospective clinical study of 173 patients with chronic nonspecific pharyngitis to show the relationship of pharyngitis with H. pylori infection. Patients were selected on the basis of inclusion criteria. The data showed a large number of patients with chronic nonspecific pharyngitis were positive for H. pylori serology and had relief with eradication therapy.

Published in International Journal of Otorhinolaryngology (Volume 7, Issue 2)
DOI 10.11648/j.ijo.20210702.12
Page(s) 11-15
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

H. pylori Serology, Chronic Nonspecific Pharyngitis, Sore Throat, PPIs, Eradication Therapy

References
[1] Aladag, İ, Bulut, Y., Guven, M., Eyibilen, A., & Yelken, K. (2008). Seroprevalence of Helicobacter pylori infection in patients with chronic nonspecific pharyngitis: Preliminary study. The Journal of Laryngology & Otology, 122 (1), 61-64. doi: 10.1017/S0022215107006743.
[2] Yılmaz, T., Bajin, M. D., Günaydın, R. Ö., Ozer, S., & Sözen, T. (2014). Laryngopharyngeal reflux and Helicobacter pylori. World journal of gastroenterology, 20 (27), 8964–8970. https://doi.org/10.3748/wjg.v20.i27.8964.
[3] Patel, D. A., Blanco, M., & Vaezi, M. F. (2018). Laryngopharyngeal Reflux and Functional Laryngeal Disorder: Perspective and Common Practice of the General Gastroenterologist. Gastroenterology & hepatology, 14 (9), 512–520.
[4] Elena Yu. Radtsig, Daniil I. Konstantinov, Extraesophageal signs of gastroesophageal reflux disease: otorhinolaryngologist’s view, Terapevticheskii arkhiv, 10.26442/00403660.2021.04.200814, 93, 4, (521-525), (2021).
[5] N Siupsinskiene, I Katutiene, V Jonikiene, D Janciauskas, S Vaitkus, Helicobacter pylori in the tonsillar tissue: a possible association with chronic tonsillitis and laryngopharyngeal reflux, The Journal of Laryngology & Otology, 10.1017/S0022215117000597, 131, 6, (549-556), (2017).
[6] Roussos, A., Tsimpoukas, F., Anastasakou, E. et al. Helicobacter pylori seroprevalence in patients with chronic bronchitis. J Gastroenterol 37, 332–335 (2002). https://doi.org/10.1007/s005350200046.
[7] Suzuki H, Nishizawa T, Hibi T. Helicobacter pylori eradication therapy. Future Microbiol. 2010 Apr; 5 (4): 639-48. doi: 10.2217/fmb.10.25. PMID: 20353303.
[8] Jung, Hye-Kyung et al. “Evidence-Based Guidelines for the Treatment of Helicobacter pylori Infection in Korea 2020.” Gut and liver vol. 15, 2 (2021): 168-195. doi: 10.5009/gnl20288.
[9] Hunt RH, Xiao SD, Megraud F, et al. Helicobacter pylori in developing countries. World Gastroenterology Organisation Global Guideline. J Gastrointestin Liver Dis. 2011; 20: 299–304.
[10] Lee JH, Ahn JY, Choi KD, et al. Nationwide antibiotic resistance mapping of Helicobacter pylori in Korea: a prospective multicenter study. Helicobacter. 2019; 24: e12592. doi: 10.1111/hel.12592.
[11] Fock KM, Graham DY, Malfertheiner P. Helicobacter pylori research: historical insights and future directions. Nat Rev Gastroenterol Hepatol. 2013; 10: 495–500. doi: 10.1038/nrgastro.2013.96.
[12] Asaka M, Kato M, Takahashi S, et al. Guidelines for the management of Helicobacter pylori infection in Japan: 2009 revised edition. Helicobacter. 2010; 15: 1–20. doi: 10.1111/j.1523-5378.2009.00738.x.
[13] Tytgat GN. Current indications for Helicobacter pylori eradication therapy. Scand J Gastroenterol Suppl. 1996; 215: 70-3. PMID: 8722387.
[14] Zhang JP, Peng ZH, Zhang J, Zhang XH, Zheng QY. Helicobacter pylori infection in the pharynx of patients with chronic pharyngitis detected with TDI-FP and modified Giemsa stain. World J Gastroenterol. 2006 Jan 21; 12 (3): 468-72. doi: 10.3748/wjg.v12.i3.468. PMID: 16489652; PMCID: PMC2855301.
[15] Cirak, Meltem Yalinay, et al. "Detection of Helicobacter pylori and its CagA gene in tonsil and adenoid tissues by PCR." Archives of Otolaryngology–Head & Neck Surgery 129.11 (2003): 1225-1229.
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  • APA Style

    Syeda Jamila Ali Tirmizey, Syed Muhammad Ali Tirmizey, Muhammad Saleem, Hafiz Sajjad Hyder Chatha, Naeem Akhtar, et al. (2022). Helicobacter Pylori Serology in Patients with Chronic Nonspecific Pharyngitis. International Journal of Otorhinolaryngology, 7(2), 11-15. https://doi.org/10.11648/j.ijo.20210702.12

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    ACS Style

    Syeda Jamila Ali Tirmizey; Syed Muhammad Ali Tirmizey; Muhammad Saleem; Hafiz Sajjad Hyder Chatha; Naeem Akhtar, et al. Helicobacter Pylori Serology in Patients with Chronic Nonspecific Pharyngitis. Int. J. Otorhinolaryngol. 2022, 7(2), 11-15. doi: 10.11648/j.ijo.20210702.12

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    AMA Style

    Syeda Jamila Ali Tirmizey, Syed Muhammad Ali Tirmizey, Muhammad Saleem, Hafiz Sajjad Hyder Chatha, Naeem Akhtar, et al. Helicobacter Pylori Serology in Patients with Chronic Nonspecific Pharyngitis. Int J Otorhinolaryngol. 2022;7(2):11-15. doi: 10.11648/j.ijo.20210702.12

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  • @article{10.11648/j.ijo.20210702.12,
      author = {Syeda Jamila Ali Tirmizey and Syed Muhammad Ali Tirmizey and Muhammad Saleem and Hafiz Sajjad Hyder Chatha and Naeem Akhtar and Faran Sarwar},
      title = {Helicobacter Pylori Serology in Patients with Chronic Nonspecific Pharyngitis},
      journal = {International Journal of Otorhinolaryngology},
      volume = {7},
      number = {2},
      pages = {11-15},
      doi = {10.11648/j.ijo.20210702.12},
      url = {https://doi.org/10.11648/j.ijo.20210702.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijo.20210702.12},
      abstract = {Sore throat is the most common complaint in ENT OPD with most of the patients suffering from pharyngitis. Chronic nonspecific pharyngitis is a very common presentation among these patients with majority experiencing only temporary relief with medications. Such patients commonly complain of burning in throat and retrosternal burning. In practice, this leads to recurrent visit of patient to the physician and otorhinolaryngologist with only temporary relief. Many of these patients have H. pylori colonization. Although H. pylori usually colonizes in gastric mucosa but there are some reports of extra gastric colonization including pharyngeal and laryngeal mucosa. To detect the presence of Helicobacter pylori there are a number of different investigations. These investigations include H. pylori serology, swab culture, stool culture and urease breath test. H. pylori serology is a very cost effective method for quick diagnosis of such patients. Eradication of H. pylori is essential for long lasting relief in these cases of chronic nonspecific pharyngitis. We have conducted a prospective clinical study of 173 patients with chronic nonspecific pharyngitis to show the relationship of pharyngitis with H. pylori infection. Patients were selected on the basis of inclusion criteria. The data showed a large number of patients with chronic nonspecific pharyngitis were positive for H. pylori serology and had relief with eradication therapy.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Helicobacter Pylori Serology in Patients with Chronic Nonspecific Pharyngitis
    AU  - Syeda Jamila Ali Tirmizey
    AU  - Syed Muhammad Ali Tirmizey
    AU  - Muhammad Saleem
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    AU  - Naeem Akhtar
    AU  - Faran Sarwar
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    DO  - 10.11648/j.ijo.20210702.12
    T2  - International Journal of Otorhinolaryngology
    JF  - International Journal of Otorhinolaryngology
    JO  - International Journal of Otorhinolaryngology
    SP  - 11
    EP  - 15
    PB  - Science Publishing Group
    SN  - 2472-2413
    UR  - https://doi.org/10.11648/j.ijo.20210702.12
    AB  - Sore throat is the most common complaint in ENT OPD with most of the patients suffering from pharyngitis. Chronic nonspecific pharyngitis is a very common presentation among these patients with majority experiencing only temporary relief with medications. Such patients commonly complain of burning in throat and retrosternal burning. In practice, this leads to recurrent visit of patient to the physician and otorhinolaryngologist with only temporary relief. Many of these patients have H. pylori colonization. Although H. pylori usually colonizes in gastric mucosa but there are some reports of extra gastric colonization including pharyngeal and laryngeal mucosa. To detect the presence of Helicobacter pylori there are a number of different investigations. These investigations include H. pylori serology, swab culture, stool culture and urease breath test. H. pylori serology is a very cost effective method for quick diagnosis of such patients. Eradication of H. pylori is essential for long lasting relief in these cases of chronic nonspecific pharyngitis. We have conducted a prospective clinical study of 173 patients with chronic nonspecific pharyngitis to show the relationship of pharyngitis with H. pylori infection. Patients were selected on the basis of inclusion criteria. The data showed a large number of patients with chronic nonspecific pharyngitis were positive for H. pylori serology and had relief with eradication therapy.
    VL  - 7
    IS  - 2
    ER  - 

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Author Information
  • Department of ENT, Government General Hospital, Ghulam Muhammad Abad, Faisalabad, Pakistan

  • Department of ENT, Abwa Medical Collage, Faisalabad, Paistan

  • Department of ENT, Aziz Fatimah Hospital, Faisalabad, Pakistan

  • Department of ENT, Faisalabad Medical University, Faisalabad, Pakistan

  • Department of ENT, Faisalabad Medical University, Faisalabad, Pakistan

  • Department of ENT, District Head Quarters, Toba Tek Sing, Pakistan

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